Thuoc ha cholesterol huyet moi Ezetimib

Thứ ba, 25 Tháng bảy 2006, 07:22 GMT+7

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Thuoc ha cholesterol huyet moi Ezetimib
Vua qua, co quan quan ly duoc pham (FDA) My da chap thuan cho luu hanh mot thuoc ha lipid moi la Ezetimib (Ten biet duoc la Zetia). Ezetimib co tac dung ha cholesterol toan phan va LDL - cholesterol trong mau xuong theo co che uc he su hap thu cholesterol tu thuc an qua niem mac ruot de vao mau.

Thuoc ha liid moi

Co nhieu nhom thuoc da duoc su dung de tri roi loan lipid huyet (chu yeu giam luong lipid, dac biet la LDL - cholesterol tuc cholesterol “xau” trong mau xuong). Nhu thuoc la cac renin gan acid mat (cholestyramin, colertipol), cac fibrat (clofibrat, fenofibrat, gemfiprozil, niacin (tuc vitamin PP), cac statin (simvastatin, atorvastatin, pravastatin…).

Ezetimib ve mat cau truc hoa hoc la mot dan chat 2-agetidinon. O ruot, ezetimib duoc chuyen hoa thanh dang glucuronid hoa co tac dung ngan su hap thu cholesterol qua niem mac ruot. Thu nghiem tren mo hinh suc vat, ezetimib co the uc che su hap thu cholesterol o ruot den 96%. Khac voi thuoc la resin gan acid mat, ezetimib khong can tro su hap thu cac chat tan trong dau mo nhu vitamin A, D hay triglycerid.

Ezetimib khong cho tac dung tai cho ma sau khi uong se hap thu vao mau (neu uong cung voi bua an se tang su hap thu den 30%), chuyen hoa o gan thanh chuyen hoa chat glucuronid moi cho tac dung. Thoi gian ban thai cua ezetimib la 13 gio o nguoi tre va 21 gio o nguoi cao tuoi. Ezetimib va dang glucuronid cua no ket hop voi protein huyet tuong den 90%, duoc dao thai qua phan va nuoc tieu.

FDA My chap thuan chi dinh cua ezetimib la dung don doc hoac phoi hop voi cac statin dieu tri cho nguoi can ha LDL - cholesterol va cholesterol toan phan. FDA My cung chap thuan dung ezetimib trong benh ly di truyen la chung “tang cholesterol mau gia dinh”.

Phong ngua cac tac dung phu

Khi dung don doc, ezetimib co the gay mot so tac dung phu nhu: dau lung, dau khop. Khi phoi hop voi cac statin, su phoi hop gay tac dung phu dau lung, dau vung thuong vi, co the lam tang men gan AST, ALT.

Ezetimib duoc cung cap duoi dang vien nen dai 10mg. Lieu dung 10mg mot lan duy nhat trong ngay, co the uong vao luc bung doi hoac no. Trong thoi gian uong thuoc, nguoi benh duoc khuyen nen an bua an chua thuc an it cholesterol. Khi phoi hop thuoc, co the uong cung luc ezetimib voi cac statin, nhung voi resin gan acid mat phai uong ezetimib 2 gio truoc hoac 4 gio sau khi uong resin. Doi voi nguoi cao tuoi, nguoi bi benh gan, than, khong can giam lieu. Dung thuoc sau 2 tuan co the lam ha LDL - cholesterol den muc toi da.

TS. DS. NGUYEN HUU DUC (Dai hoc Y Duoc TP. HCM)
Bao Suc khoe & Doi song

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