Tac dung phu cua thuoc statin hiem xay ra

Thứ sáu, 27 Tháng bảy 2012, 11:08 GMT+7

Thuoc tri roi loan lipid huyet (nhieu nguoi con goi la thuoc ha lipid huyet) la thuoc co tac dung giup cac chat beo (thuong goi la mo) co trong mau nhu cholesterol toan phan, LDL-cholesterol, HDL-cholesterol, triglycerid tro lai gioi han binh thuong. Co nhieu nhom thuoc ha lipid huyet, trong do duoc dung pho bien hien nay la nhom cac statin (vi ten thuoc co van cuoi la statin).

>> Thuoc va nhung tac dung "khuyen mai" bat ngo

>> Than trong khi dung thuoc ha mo mau

Khi su dung cac statin, tac dung phu luu y nhat la “tieu co van” (rhabdomyolysis). Day la benh ly co the gay chet nguoi do cac te bao co van bi phan huy, giai phong cac chat co ben trong te bao, trong do co myoglobin, dua den tieu tien ra myoglobin va chinh chat nay lam nghen than dan den suy than. Dau hieu ban dau cua chung nay la bap thit bi dau nhuc, yeu co, co co (thuong gap o co bap chan, co lung), sau do di tieu voi nuoc tieu mau do dam do thai myoglobin (nguoi dung thuoc can luu y cac dau hieu de ngung thuoc va den gap bac si ngay). Cung vi gay tac dung phu vua ke tram trong ma mot statin la cerivastatin (Baycol, Lipobay) da bi cam luu hanh.

Ve tac dung phu lam viem gan, ton thuong gan got (gan Achiles) do dung thuoc nhom statin chi moi duoc cong bo thong qua mot nghien cuu o Truong dai hoc Rouen (Phap). Nghien cuu nay dua vao viec hoi cuu du lieu tac dung phu cua  4.597 benh nhan da dung thuoc statin va ghi nhan co 92 benh nhan co tac dung phu vua ke. Tuc la chi co 2% cua so benh nhan duoc nghien cuu la bi tac dung phu chu khong phai 57% benh nhan bi (nhu mot so ban doc hoi). Theo nghien cuu, 57% la ti le benh nhan trong so 92 benh nhan bi tac dung phu duoc ghi nhan ton thuong gan trong vong mot nam sau khi dung statin (43% con lai bi ton thuong gan hon mot nam sau khi dung  thuoc). Nhu vay, chi co mot so it nguoi bi tac dung phu va thoi gian dung thuoc phai keo dai ca nam tro len (khi ngung dung thuoc thi tac dung phu bien mat).

Tac dung phu gay viem gan, ton thuong gan con co the xay ra o mot so thuoc khac, dac biet khang sinh thuoc nhom fluoroquinolin.

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Hinh minh hoa

Doi voi nguoi su dung thuoc, hien nay van co the an tam dung cac thuoc statin khi duoc bac si chi dinh. Chi luu y khi dang dung thuoc ma cam thay co nhung trieu chung bat thuong nhu dau co, yeu co (do tac dung phu tieu co van) hoac sung, nong, do, dau, co cung o vung gan nao do, dac biet gan got (do tac dung phu ton thuong gan moi phat hien) thi ngung thuoc va den bac si kham hoac tai kham. Xin duoc nhac lai cac tac dung phu vua ke thuoc loai hiem xay ra chu khong thuong xay ra.   

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